Expressions and significances of prognosis by MiR-451a in nasopharyngeal carcinoma in Guangxi
10.3969/j.issn.1006-5725.2016.15.012
- VernacularTitle:广西地区鼻咽癌miR-451a表达与预后的关系
- Author:
Xianglan MO
;
Wu YIN
;
Haiming WEI
;
Guiping LAN
;
Yongfeng SI
;
Minyan ZHOU
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal carcinoma;
MiR-451a;
Real time RT-PCR;
Prognosis
- From:
The Journal of Practical Medicine
2016;32(15):2462-2464
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression level and the significances of prognosis by miR-451a in nasopharyngeal carcinoma (NPC) in Guangxi. Methods The expressions of miR-451a in 89 cases of nasopharyngeal carcinoma were detected by real time RT-PCR. The relation among the expression level , the clinicopathologic features of NPC and its prognosis were analyzed. Results The expression of miR-451a were found in all of nasopharyngeal carcinoma. The expression level of miR-451a in nasopharyngeal carcinoma was negative correlated to overall survival and disease free survival (P = 0.01,P = 0.04). Conclusions miR-451a may play a key role in detection of nasopharyngeal carcinoma with poor prognosis.
