Prenatal diagnosis of unbalanced reciprocal translocations at the second trimester
10.3969/j.issn.1006-5725.2016.15.019
- VernacularTitle:孕中期染色体非平衡易位胎儿的产前诊断分析
- Author:
Xiaojin LUO
;
Biyun GUO
;
Liang HU
;
Jian RAN
;
Tao YU
;
Fengxiang WEI
- Publication Type:Journal Article
- Keywords:
Prenatal diagnosis;
Chromosomal abnormalities;
Unbalanced translocations
- From:
The Journal of Practical Medicine
2016;32(15):2483-2485
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the distribution of prenatal indications , clinical features and pregnant outcomes of chromosomal unbalanced reciprocal translocations atthe second trimester. Methods The data on 35 fetuses with unbalanced reciprocal translocations between May 2011 and March 2016 were retrospectively analyzed and reviewed. Results Of 35 fetuses with unbalanced translocations , 29 (82.86%) showed ultrasound abnormalities,and 6 (17.14%) had no significant clinical features. 8 were de novo, and the other 27 were parental inherited. All the 35 women had to terminate the pregnancy. Conclusions Ultrasound abnormalities are associated with chromosomal unbalanced reciprocal translocations at the second trimester , and most unbalanced translocations fetuses origin from parental carrier of balanced translocations.
