Drug reaction with eosinophilia and systemic symptom induced in a 9-year-old boy.
10.4168/aard.2016.4.4.296
- Author:
Han Sol SONG
1
;
Woo Hyeok CHOI
;
Won Bok CHOI
;
Seung YANG
;
Il Tae HWANG
;
Hey Sung BAEK
Author Information
1. Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea. paviola7@hanmail.net
- Publication Type:Case Report
- Keywords:
Drug eruptions;
Drug hypersensitivity;
Eosinophilia;
Acetaminophen
- MeSH:
Acetaminophen;
Child*;
Diagnosis;
Drug Eruptions;
Drug Hypersensitivity;
Eosinophilia*;
Exanthema;
Fever;
Humans;
Hypersensitivity;
Ibuprofen;
Leukocytosis;
Liver;
Male*;
Methylprednisolone
- From:Allergy, Asthma & Respiratory Disease
2016;4(4):296-300
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The drug reaction with eosinophilia and systemic symptom (DRESS) is a severe adverse drug-induced reaction. Acetaminophen is extensively used as an over-the-counter drug as well as a medical therapeutic. In spite of its frequent use, drug eruptions related to DRESS caused by acetaminophen are rare. This case report describes a 9-year-old boy who experienced fever and maculopapular skin rashes after taking acetaminophen. Leukocytosis with marked eosinophilia and slightly elevated levels of liver enzymes were observed. Symptoms resolved after withdrawal of acetaminophen, followed by intravenous methylprednisolone administration. The diagnosis of DRESS induced by acetaminophen was confirmed by an oral challenge test after 2 months. No allergic reactions to ibuprofen were observed.
