Wenshen-Zhuanggu decoction combined with calcium preparations and vitamin D in the ;treatment of senile osteoporosis
10.3760/cma.j.issn.1673-4246.2016.08.010
- VernacularTitle:温肾壮骨汤联合钙制剂及维生素D治疗老年性骨质疏松症临床研究
- Author:
Linyan FAN
- Publication Type:Journal Article
- Keywords:
Osteoporosis;
Aged;
Calcimimetic agents;
Vitamin D;
Wenshen-Zhuanggu decoction;
Bone density;
Osteocalcin;
Alkaline phosphatase
- From:
International Journal of Traditional Chinese Medicine
2016;38(8):705-708
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effects of Wenshen-Zhuanggu decoction combined with calcium preparations and vitamin D in the treatment of senile osteoporosis. Methods A total of 82 patients with osteoporosis were randomly divided into the control group and the observation group, 41 in each group. The control group was given conventional treatment (calcium preparations, vitamin D). Based on the treatment of control group, the observation group was combined with traditional Chinese medicine (TCM) formula Wenshen-Zhuanggu decoction. Both groups were treated for 10 weeks, and followed up for 3 months. The improvement of osteoporosis, bone function related indexes bone mineral density (BMD), serum bone gla protein (BGP), serum bone alkaline phosphatase (BALP) and incidence of osteoportic fractures and adverse reactions in the two groups were observed. Results The effective rate of symptom remission in the observation group was 90.24% (37/41) while in the control group was 70.73% (29/41) (χ2=4.970, P<0.05), and the bone function related indexes of both groups (BMD, BGP, BALP) were significantly improved after treatment. Compared with the control group, the BMD (0.84 ± 0.05 g/cm2 vs. 0.78 ± 0.06 g/cm2, t=4.919), BGP (28.64 ± 12.14 ng/ml vs. 21.32 ± 11.25 ng/ml, t=2.832) and BALP (18.11 ± 6.15 U/L vs. 14.54 ± 6.21 U/L, t=2.615) in the observation group were significantly higher than those in the control group (P<0.05). The incidence rates of adverse reactions (7.32%vs. 24.39%) and osteoportic fractures (9.76%vs. 26.83%) in the observation group were significantly lower than those in the control group (P<0.05). Conclusions Wenshen-Zhuanggu decoction combined with calcium preparations and vitamin D in the treatment of senile osteoporosis can effectively alleviate symptoms and preventing senile OP fractures..
