Hashimoto's encephalopathy with disturbance of consciousness and dementia as initial symptoms: report of 2 cases and literature review

VernacularTitle:以痴呆和意识障碍为首发症状的桥本脑病二例并文献复习
Author: Xiaodan FU ; Lingying YU ; Xianfeng ZHANG ; Chu ZHANG
Publication Type:Journal Article
Keywords: Braim diseases,Hashimoto's diseases; Signs and symptoms
From: Chinese Journal of General Practitioners 2016;15(8):635-638
CountryChina
Language:Chinese
Abstract: Two eases of Hashimoto's encephalopathy (HE) are reported and relative literature is reviewed in this article.Both cases were female,with disturbance of consciousness and dementia as initial symptoms.Marked increase of anti-thyroid antibodies was found in serum of the patients.The symptoms disappeared after steroids and maintenance therapies.A total of 126 cases of HE in Chinese literature were retrieved from 2006 to 2015 through the databases of China National Knowledge Infrastructure and Wanfang Med Online.The male/female radio was 1 ∶ 6 with an average age of 51.3 years.The clinical manifestations included cognitive impairment (44.5％),epilepsy (38.3％),psychiatric disorders (27.3％),stroke-like symptoms (25.8％),disturbance of consciousness (24.2％),and extrapyramidal symptoms (20.3％).Good response to steroids was observed in 77.2％ HE patients.Analysis indicates that HE is an autoimmune disease with the presence of neurological and psychiatric manifestations,elevated titers of anti-thyroid antibodies in serum and well response to steroids,with a good prognosis.