A Meta analysis of predictive value of Wilms tumor gene 1 level on long-term outcome of acute myeloid leukemia

VernacularTitle:Wilms瘤基因1表达与急性髓系白血病长期预后关系的Meta分析
Author: Wei DENG ; Lei CAO ; Rong CHAO ; Li WANG
Publication Type:Journal Article
Keywords: Acute myeloid leukemia; Wilms tumor 1 gene; Meta analysis; Long-term outcome
From: Clinical Medicine of China 2016;32(5):462-466
CountryChina
Language:Chinese
Abstract: Objective To explore the predictivevalue of Wilms tumor gene 1 (WT1) level on long-term outcome of acute myeloid leukemia(AML).Methods The study in accordance with the inclusion criteria were collected by computer retrieving PubMed,ScienceDirect,EBSCO,Web of Science,CNKI,VIP and Wan Fang database.The retrieval time was from inception to March 2015,the two researchers according to the inclusion and exclusion independently selected studies and extracted the data and assessed the quality,then Revman 5.2 was used for Meta analysis.Results There were 11 relevant published articles were included with 1497 case patients.Meta analysis showed that High expression of WT1 gene was a negative factor for overall survival rate (OS) and disease free survival (DFS) in patients with AML (HR =1.34,95％CI 1.14-1.58,P ＜ 0.01;HR =1.35,95％CI 1.11-1.64,P =0.003).For cytogenetically normal AML patients,the high expression of WT1 gene was still the unfavorable factor of OS (HR =1.41,95％ CI 1.01-1.99,P =0.05).Conclusion WT1 expression level could be an useful prognosis long-term outcome marker for AML patients.