Updates of microRNA-21 in the occurrence and development of cholangiocarcinoma
10.3760/cma.j.issn.1673-9752.2016.07.020
- VernacularTitle:microRNA-21在胆管癌发生发展中的研究进展
- Author:
Heihei LI
;
Jiansheng LIU
- Publication Type:Journal Article
- Keywords:
Bile duct neoplasms;
Micro RNA;
Micro RNA-21
- From:
Chinese Journal of Digestive Surgery
2016;15(7):751-754
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA) is an endogenous nonprotein-coding short-chain RNA,and it involves in the evolution of a variety of malignant tumors through targeted inhibition of mRNA translation or mRNA cleavage of gene expression regulation cancer or tumor suppressor genes,meanwhile,is also an important molecule in the occurrence and development processes of tumor.In the recent studies,miRNA has played an important role in the proliferation,apoptosis and invasion of cholangiocarcinoma cells,and it maybe become a new biomarker for the early diagnosis,assessment of prognosis and chemotherapy of cholangiocarcinoma.
