The neuroendocrine hormone changes and clinical significance in the syndrome of brain injury
10.3760/cma.j.issn.1674-6090.2016.04.014
- VernacularTitle:颅脑损伤后综合征神经内分泌激素水平变化及临床意义
- Author:
Weiguang XU
;
Zhan ZHAO
;
Liming YIN
;
Dequan ZHONG
;
Wentao WANG
- Publication Type:Journal Article
- Keywords:
Brain Injury;
Syndrome;
Neuroendocrine;
Hormone
- From:
Chinese Journal of Endocrine Surgery
2016;10(4):317-319
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the incidence and clinical significance of abnormal neuroendocrine hormone in patients with the syndrome of brain injury.Methods 67 cases with the syndrome of brain injury were included in the study group,and 95 cases without the post traumatic syndrome after brain injury were included in the control group.The level of FT3,FT4,TSH,growth hormone(GH),andrenocortico hormone(ACTH),cortisol (Cor),prolactin(PRL),testosterone (T),estradiol (E2),follicular stimulating hormone (FSH),luteotropic hormone (LH),and progesterone (P) in peripheral blood were measured by radioimmunoassay.The incidence of the abnormal neuroendocrine hormone after brain injury was statistically analyzed.Patients with abnormal hormone were given hormone replacement therapy and the curative effects were observed.Results The incidence of neuroendocrine hormone abnormalities was 38.8％ in patients with the syndrome of brain injury,while it was 10.5％ in the control group.There was significant difference between the 2 groups(P＜0.05).The symptom remission rate was 88.5％ after hormone treatment.Conclusions There was a high incidence of abnormal neuroendocrine hormone secretion in patients with the syndrome of brain injury.The hormone level may be used as an important index to guide clinical therapy.
