Surgical resection of stage Ⅲ and Ⅳa invasive thymoma after inductive chemoradiotherapy
10.3760/cma.j.issn.1674-6090.2016.03.013
- VernacularTitle:诱导治疗后手术切除Ⅲ、Ⅳa期侵袭性胸腺瘤的临床分析
- Author:
Jiang ZHU
;
Xiang WANG
;
Jintao HE
- Publication Type:Journal Article
- Keywords:
Invasive thymomas;
Induction treatment;
Operation
- From:
Chinese Journal of Endocrine Surgery
2016;10(3):228-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the diagnosis and inductive chemoradiotherapy of stage Ⅲ and stage Ⅳa invasive thymoma.Methods Clinical data of 13 cases with incomplete resected invasive thymoma were analyzed retrospectively,among which 8 cases were in stage Ⅲ and 5 cases in stage Ⅳa.All the 13 cases had invasion of major vessels,pericardial and lung tissues,or had metastasis of pleura and pericardium.Each patient got pathological diagnosis by fine needle aspiration,video-assisted thoracoscopic biopsy or anterior mediastinal biopsy.After 3 cycles of NP or CAP inductive chemotherapy and synchronous radiotherapy,tumors shrank and got palliative or complete surgical resection.The Follow up ranged from 2.8 to 9 years.Results All the 13 cases were malignant thymoma,including 4 cases of type B2,6 cases of type B3 and 5 cases of type C.7 patients got radical resection and 2 got palliative resection.9 patients survived more than 3 years after operation,7 patients survived more than 5 years,one patient even lived 8 years,and the other 4 patients without getting surgery died in 4 years.Conclusion Inductive chemoradiotherapy could shrink stage Ⅲ and stage Ⅳa invasive thymoma,reduce clinical stage,improve the resection rate,and prolong survival.
