Relationship of vitamin D in children with sepsis/severe sepsis and outcomes in PICU
10.3760/cma.j.issn.1671-0282.2016.06.004
- VernacularTitle:脓毒症/严重脓毒症患儿维生素D水平与预后
- Author:
Bingru YIN
;
Suyun QIAN
;
Yibing CHENG
;
Guoping LU
;
Yimin ZHU
- Publication Type:Journal Article
- Keywords:
Sepsis;
Severe sepsis,Children;
Vitamin D Deficiency;
Outcomes
- From:
Chinese Journal of Emergency Medicine
2016;25(6):709-713
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the vitamin D status in children with sepsis/severe sepsis in pediatric intensive care unit (PICU) in order to explor the association between vitamin D status and clinical outcomes,in turn to provide evidence for optimizing nutrition support.Methods It was a prospective,observational,multi-center study,carried out in patients with sepsis/severe sepsis from March 1,2013,to March 30,2014,in the PICUs of three tertiary-care children's hospitals.Total serum 25-hydroxy vitamin D [25 (OH) D] was measured by using an enzyme-linked immunosorbent assay at admission.The association of vitamin D status at admission with length of PICU length of stay,total hospital stay,in-hospital mortality,28-days mortality and costs were analyzed.Results A total of 194 patients includng 117 boys (60.3%)and 77 girls (39.7%) were enrolled.There were 96 patients with sepsis and 98 with severe sepsis.The mortality on discharge and 28 days were 6.7% and 24.2% respectively.The median vitamin D level was 9.79 ng/mL (5.32,18.46) at admission.Of them 77.8% (151/194) had vitamin D deficiency and 50.5% (98/194) had severe vitamin D deficiency.Patients with severe vitamin D deficiency,had higher mortality on discharge (P =0.011).Vitamin D status had no significant correlations with 28 days mortality,length of PICU stay,total hospital stay and costs.Conclusions More than three-quarters (77.8%) of children with sepsis/severe sepsis in PICUs had Vitamin D deficiency.Patients with severe vitamin D deficiency at admission had higher risk of mortality at discharge.