The role of autophagy in neuronal ischemic injury and its relationship with apoptosis and necrosis
10.3760/cma.j.issn.1671-0282.2016.06.034
- VernacularTitle:自吞噬在神经细胞缺血性损伤中的作用及其与凋亡和坏死的关系
- Author:
Kongmiao LU
;
Shuming PAN
- Publication Type:Journal Article
- Keywords:
Autophagy;
Neuron;
Hypoxia-Ischemia,Brain;
Apoptosis;
Necrosis
- From:
Chinese Journal of Emergency Medicine
2016;25(6):843-846
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is the major cause of disability and death.Although autophagy is widely involved in the process of acute brain ischemia,the exact role of autophagy is still unclear.As autophagy is a double-edged sword,its protect or damage impact mainly depends on the degree of phagocytosis.In general,moderate phagocytosis can effectively remove excess metabolites,aging organelles,etc;whereas the excessive autophagy is vulnerable to autophagy-like cell death by virture of the normal intracellular organelles and materials degraded by lysosome.In conclusion,this review focuses on the following two points:1.What's the role of autophagy in the ischemic brain injury——protective or damage 2.How does autophagy interact with apoptosis and necrosis.
