Effect of different type of exercise on mitochondrial homeostasis in rats with myocardial infarction
10.3760/cma.j.issn.1671-0282.2016.05.015
- VernacularTitle:不同运动方式对心肌梗死大鼠心肌线粒体稳态的影响
- Author:
Wei HE
;
Yuming LI
;
Xin ZHOU
;
Peng PENG
;
Yongsheng QIN
;
Hai BO
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
High-intensity interval exercise training;
Moderateintensity continuous training;
Ventricular remodeling;
Mitochondrial homeostasis
- From:Chinese Journal of Emergency Medicine
2016;25(5):617-623
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigated the different effect of moderate-intensity continuous training (MCT) and high-intensity interval exercise training (HIT) on ventricular remodeling and mitochondrial homeostasis after acute myocardial infarction (AMI).Methods The AMI rat model was achieved by ligating coronary artery.The AMI and sham operation rats were randomly (random number) divided into four groups:sham operation group (Sham),AMI control group (AMI),AMI MCT group (AMI + M),and AMI HIT group (AMI + H).Animals in the AMI + M and AMI + H groups underwent 4 weeks MCT and HIT respectively.Five weeks after AMI,hemodynamic changes,mitochondrial bioenergetics,and PINK1,Beclinl,Mfn2,Drp1,Tfam,COXⅣ,PGC-1α were detected.Results Comparing with AMI group,in AMI + M and AMI + H groups,Beclin1,PINK1,Mfn2 and PGC-1α expression elevated significantly (P ＜0.05 or P ＜0.01),whereas ROS generation and Drp1 expression showed dramatic decrease (P ＜ 0.05 or P＜0.01).In addition,in AMI + H group,±dp/dt max,mitochondrial membrane potential,ATP synthesis activity,Tfam and COXⅣ expression improved significantly (P ＜ 0.05).Comparing with AMI + M group,in AMI + H group,± dp/dt max,PGC-1α,Tfam and COX Ⅳ expression improved significantly (P ＜ 0.05).Conclusions HIT is superior to MCT for ameliorating ventricular remodeling and mitochondrial homeostasis after AMI.
