Effects of the tryptophan 2,3-dioxygenase in tryptophan metabolism and immunoregulation
10.3760/cma.j.issn.1673-4203.2016.07.018
- VernacularTitle:色氨酸2,3-双加氧酶在色氨酸分解代谢及免疫调节中的作用
- Author:
Shanbao LI
;
Junming XU
- Publication Type:Journal Article
- Keywords:
Tryptophan 2,3-dioxygenase;
Tryptophan;
Cancer therapy;
Immune tolerance;
Liver transplantation
- From:
International Journal of Surgery
2016;43(7):491-494
- CountryChina
- Language:Chinese
-
Abstract:
Tryptophan 2,3-dioxygenase (TDO)is the rate-limiting enzyme in the catabolism of Trp along the kynurenine pathway.Trp is mainly catabilized by the TDO in the liver,which could not only regulate the concentration of the Trp and suppress the T cells proliferation,but also participate in antibacterial action and inflammatory response.The metabolin kynurenines as an endogenous ligand of the AhR receptor,the TDO enzymes,Kyn and AhR form the TDO-Kyn-AhR pathway have effects of regulatory the growth of tumor.With the research of the mechanism of immune regulation goes futher,it is expected to be a promising prospect in cancer therapy and the immune tolerance of transplantation.We reviewed in the article,which summarized the TDO mediated catabolism of Trp and immunomodulatory effect.
