Progress of the relationship between eukaryotic initiation factor 5A and human diseases
10.3760/cma.j.issn.1673-4203.2016.07.017
- VernacularTitle:真核细胞翻译起始因子5A与人类疾病关系的研究进展
- Author:
Qingyun ZHOU
;
Wuke WANG
;
Chuxiao SHAO
;
Chaoyong TU
- Publication Type:Journal Article
- Keywords:
Eukaryotic initiation factors;
Human;
Diseases
- From:
International Journal of Surgery
2016;43(7):486-491
- CountryChina
- Language:Chinese
-
Abstract:
Eukaryotic initiation factor 5A (eIF5A),which is ubiquitous in the eukaryote,is the unique protein containing the special lysine hypusine.There are evidences show that eIFSA is involved in the progress of translation,peptide elongation and peptide bond formation,and takes part in the occurrence and development of various human diseases.The activation of eIF5A is essential to its biological function.The active eIFSA is involved in the growth of plasmodium and contributes to tumor proliferation.And it can act as nuclear output protein to integrate special mRNA,and in this way the special mRNA can shuttle between the nucleus and cytoplasm.Basing on these findings,the scientists pay more attention to eIF5A,and deem it as a direction to cure some related human diseases.
