Taxane resistance in metastatic breast cancer and novel microtubule-targeting agents
10.3760/cma.j.issn.1673-422X.2016.08.015
- VernacularTitle:晚期乳腺癌紫杉类耐药及其新型抗微管治疗
- Author:
Yuan HUANG
;
Danli LIU
;
Xiaojia WANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Taxoids;
Drug resistance;
Microtubules
- From:
Journal of International Oncology
2016;43(8):622-624
- CountryChina
- Language:Chinese
-
Abstract:
The development of primary or acquired taxane resistance inevitably becomes to be the main problem.Ixabepilone is effective in metastatic breast cancer (MBC) patients including those heavily pretreated or resistant to taxanes.Eribulin has been used for the treatment of MBC patients who have received at least two prior chemotherapy regimens.New microtubule-targeting agents are promising to be effective options for patients progressing after standard taxane-containing chemotherapy.
