Mechanism of breast cancer metastasis suppressor gene 1 inhibiting tumor metastasis
10.3760/cma.j.issn.1673-422X.2016.08.014
- VernacularTitle:乳腺癌转移抑制基因1抑制肿瘤转移的作用机制
- Author:
Li MAO
;
Caiping CUI
;
Jing ZHANG
;
Ping ZHOU
- Publication Type:Journal Article
- Keywords:
Gene,neoplasm;
Tumor metastasis;
Breast cancer metastasis suppressor gene 1;
Inhibiting effect
- From:
Journal of International Oncology
2016;43(8):619-621
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer metastasis suppressor gene 1 (BRMS1) significantly reduces the invasion and metastasis of cancer cells.BRMS1 gene expression is decreased or deleted in the cells of various malignant tumors.BRMS1 gene can inhibit tumor cells invasion and metastasis by means of regulating gene transcription and protein translation by phosphoinositide signaling and nuclear factor-κB (NF-κB) signaling pathways,repairing intercellular communication and interacting with the mSin3-histone deacetylase (HDAC) complex,estrogen receptor and other proteins.BRMS1 gene may be a new target for the gene treatment of tumor metastasis.
