Correlation between thyroid antibody level and carotid atherosclerotic plaque in patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2016.06.007
- VernacularTitle:甲状腺抗体水平与急性缺血性卒中患者颈动脉粥样硬化斑块的相关性
- Author:
Yue ZHANG
;
Guorong BI
- Publication Type:Journal Article
- Keywords:
Thyroiditis,Autoimmune;
Autoantibodies;
Stroke;
Brain Ischemia;
Carotid Artery Diseases;
Atherosclerosis;
Plaque,Atherosclerotic;
Risk Factors
- From:
International Journal of Cerebrovascular Diseases
2016;24(6):524-528
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between thyroid antibody level and carotid atherosclerotic plaque in patients with acute ischemic stroke.Methods Consecutive patients with acute ischemic stroke were enrolled retrospectively.They were divided into a non-plaque group and a plaque group according to the findings of carotid artery color-Doppler ultrasonography.The plaque group was redivided into a stable plaque subgroup and a non-stable plaque subgroup.Chemiluminescence method was used to measure the serum thyroperoxidase antibodies (TPOAb) and thyroglobulin antibodies (TGAb) levels and they were compared.Results A total of 383 patients were enrolled in the study,including 116 (30.3％) did not have plaque and 267 (69.7％) had plaque,68 of them had unstable plaque,and 199 had stable plaque.The level of TGAb in the plaque group was significantly higher than that in the non-plaque group (Z =-4.826,P ＜0.001).Multivariate logistic regression analysis showed that the level of TGAb might be an independent risk factors for carotid plaque (odds ratio 1.007,95％ confidence interval 1.001-1.012;P =0.016).The serum level of TPOAb in the stable plaque group was significantly higher than that in the unstable plaque group (Z =-2.114,P=0.035),but multivariate logistic regression analysis showed that it was not the independent risk factor for unstable plaque (odds ratio 1.001,95％ confidence interval 0.996-1.006;P =0.786).Conclusions The level of serum thyroid antibodies increased in patients with acute ischemic stroke,especially the increased level of TGAb might be associated with the occurrence and development of carotid atherosclerotic plaque,however,it was not associated with the plaque stability.
