MicroRNA-146a C ＞ G polymorphism and the risk of ischemic stroke: a meta-analysis
10.3760/cma.j.issn.1673-4165.2016.04.006
- VernacularTitle:微小RNA-146a C＞G多态性与缺血性卒中风险:汇总分析
- Author:
Shunchang SUN
;
Rongyao HOU
;
Xudong PAN
;
Xiaoyan ZHU
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
MicroRNAs;
Polymorphism,Single Nucleotide;
Meta-Analysis
- From:
International Journal of Cerebrovascular Diseases
2016;24(4):336-342
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between MicroRNA-146a (miR-146a) C ＞ G polymorphism and ischemic stroke.Methods The case control studies of the relationship between miR-146a polymorphism and ischemic stroke published before February 2016 were retrieved comprehensively.The Statal2.0 software package was used to conduct the meta-analysis.The odds ratio (OR) and 95％ confidence interval (CI) were used to evaluate the strength of association between the polymorphisms and the risk of ischemic stroke.Results A total of 8 articles were enrolled,including 2 891 patients in the case group and 4 019 in the control group.The selected literature did not have obvious publication bias.In the general population,the dominant model (GG + CG vs.CC:OR 1.011,95％ CI 0.863-1.185;P =0.889),recessive model (GG vs.CG + CC:OR 0.999,95％ CI 0.761-1.311;P=0.994),heterozygous model (CG vs.CC:OR 1.052,95％ CI 0.943-1.173;P =0.368),homozygous model (GG vs.CC:OR 1.114,95％ CI 0.819-1.515;P =0.491),and allele model (G vs.C:OR 1.062,95％ CI0.919-1.227;P=0.413) did not show significant correlation between the miR-146a C ＞ G polymorphism and the risk of ischemic stroke.Subgroup analysis showed that the miR-146a C ＞ G polymorphism was not associated with the onset risks of large artery atherosclerotic and small arterial occlusive stroke.Conclusions According to the literature available,the miR-146a C ＞ G polymorphism may not be significantly associated with the risk of ischemic stroke.
