Toll-like receptors and respiratory infectious diseases
10.3760/cma.j.issn.1673-4408.2016.08.007
- VernacularTitle:Toll样受体与呼吸道感染性疾病的研究进展
- Author:
Wenna YUE
- Publication Type:Journal Article
- Keywords:
TLR2;
TLR4;
Infection
- From:
International Journal of Pediatrics
2016;43(8):618-621
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptor,TLR (TLR) can sense invading pathogens,the acute inflammatory response in the body,chronic airway inflammation and pathophysiology of allergic diseases and play an important role in the immune defense response.Among them,TLR2,TLR4 most prominent role and become a hot research topic.This paper summarizes the importance of TLR2,TLR4 in the pathogenesis of respiratory tract infections,and pointed out by interfering with TLR2,TLR4 signal transduction pathway or reduced TLR2,TLR4g role may help to weaken the disease or improve the prognosis,which provides a new way of thinking and clues for the treatment of clinical common diseases.
