Progress on the study of pharmacokinetics of digoxin and rational drug use in pediatrics
10.3760/cma.j.issn.1673-4408.2016.08.006
- VernacularTitle:小儿地高辛代谢及合理临床应用研究进展
- Author:
Yi JIAO
- Publication Type:Journal Article
- Keywords:
Digoxin;
Pharmacokinetics;
Rational drug use;
Factor;
Children
- From:
International Journal of Pediatrics
2016;43(8):614-617
- CountryChina
- Language:Chinese
-
Abstract:
Digoxin is the most frequently prescribed cardiac glucoside in pediatrics.Owing to its pharmacokinetics profile and narrow therapeutic index,some cases such as digoxin intoxication or dose insufficient are not rare.Recent evidence suggests that age,weight,hepatic and renal function,intestinal microbiome,drug interactions and others have influence on the pharmacokinetics of digoxin.So more attentions should be paid to the influencing factors mentioned above when digoxin concentration is monitored except observing intoxication to ensure rational drug use.
