The research progress of DNA methylation in the pathogenesis and treatment of epilepsy
10.3760/cma.j.issn.1673-4408.2016.06.007
- VernacularTitle:DNA甲基化在癫(癎)发病机制及治疗中的研究进展
- Author:
Xiaole WANG
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Epigenetics;
DNA methylation;
Treatment
- From:
International Journal of Pediatrics
2016;43(6):449-452
- CountryChina
- Language:Chinese
-
Abstract:
DNA methylation is an important epigenetic modification,functioning under the regulation of DNA methyltransferase(DNMT),interacting with other epigenetic mechanisms and participating in the regulation of gene expression and differentiation process of cells.Many DNA methylation related changes are found in epilepsy and the emerging role of DNA methylation in epileptogenesis is becoming even more obvious.Here,we discuss the research progress of DNA methylation in the pathogenesis of epilepsy,and the perspectives of epigenetic medicine as new therapeutic strategy in epilepsies.
