A comparative analysis of EEG and cognitive function in children with benign epilepsy associated with central temporal spikes
10.3760/cma.j.issn.1673-4408.2016.04.017
- VernacularTitle:伴中央颞区棘波的儿童良性癫(痫)治疗前后脑电图与认知功能的对比分析
- Author:
Jing ZHANG
;
Fang CHEN
;
Mei JIN
;
Yakun DU
;
Suzhen SUN
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Benign childhood epilepsy with centro-temporal spikes;
Cognitive function;
P300;
Intelligence
- From:
International Journal of Pediatrics
2016;43(4):329-332
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the EEG discharge index, intelligence test and event-related potential P300 in BECT, and to analyze the change of EEG discharge index and cognitive function before and after the treatment.Methods Sixty patients with BECT were enrolled in this study, they were treated with EEG, intelligence tests and P300 before and after the treatment.Results (1) The EEG discharge index were reduced remarkly after treatment in BECT with levetiracetam and lamotrigine, the difference was statistically significant (P ＜ 0.05).(2) Comparing before and after 3 or 6 months treatment, the latency of P300 had reduced with significant difference (P ＜ 0.05).(3) After 3 months treatment, VIQ and FIQ has no obvious improvement, but PIQ has improved.After 6 months treatment, VIQ、 PIQ and FIQ were improved.The difference was statistically significant (P ＜ 0.05).(4) There was a negative correlation of EEG P300 latency (r =0.175), as well as there was a negative correlation between EEG discharge index and intelligence test (r =0.044).Conclusion There is impaired cognitive function in BECT, especially the more frequently the EEG discharge, the more extended of P300 latency, as well as the more serious damage of intelligence and cognition after treatment.The intelligence were improved after treatment with Levetiracetam and lamotrigine, the longer the treatment time, the more obvious of intelligence levels improve.
