Research progress on the mitochondrial respiratory chain complex Ⅴ in sepsis
10.3760/cma.j.issn.1673-4408.2016.04.006
- VernacularTitle:脓毒症与线粒体呼吸链酶复合物Ⅴ研究进展
- Author:
Xiuxiu LU
- Publication Type:Journal Article
- Keywords:
Sepsis;
Complex Ⅴ;
Mitochondrial ATP synthase
- From:
International Journal of Pediatrics
2016;43(4):284-288
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a complex pathophysiological disorder arising from a systemic inflammatory response to infection.It is considered as a major cause of death among critically ill patients in intensive care units.Mitochondrial dysfunction and impaired oxidative phosphorylation have been implicated in the pathogenesis of sepsis.The mitochondrial respiratory chain complex Ⅴ is the key enzyme of oxidative phosphorylation.It is response for ATP synthesis and there is a reduction of complex Ⅴ activity in the early sepsis.However,in the late sepsis,under ischemic conditions, it accounts for significant ATP hydrolysis and the activity is up-regulation.Here,this review focuses on the changes of complex Ⅴ activity,mechanism of regulation and therapy in sepsis.
