Effects of oxycodone early analgesia on stress response in patients undergoing uvulopalatopharyngoplasty
- VernacularTitle:悬雍垂腭咽成形术后羟考酮镇痛对糖尿病患者应激反应的影响
- Author:
Rui ZHAO
;
Haichun LI
;
Yahui LIU
;
Li YUAN
;
Na PANG
;
Junjie LI
;
Yue MA
;
Jiajian WU
;
Fei LIU
- Publication Type:Journal Article
- Keywords:
Oxycodone;
Diabetics;
Early analgesia;
Stress response;
Uvulopalatopharyngo-plasty
- From:
The Journal of Clinical Anesthesiology
2016;32(9):845-847
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study effects of oxycodone post-operative early analgesia on stress re-sponse with in diabetics undergoing uvulopalatopharyngoplasty (UPPP).Methods Eighty patients undergoing UPPP,53 males,27 females,aged 28-65 years,ASA Ⅰ or Ⅱ were randomly divided in-to two groups(n =40).1 5 minutes before the end of the operation,group O was intravenously given oxycodone 0.07 mg/kg;Group F fentanyl 0.7 μg/kg.The patients of the two groups were sampled venous blood 3 ml in the morning of operation (T1 ),postoperative 1 hour (T2 ),postoperative 3 hours (T3 )for determination of serum cortisol (Cor),serum insulin(Ins),serum C-peptide(C-P)u-sing electrochemical luminescence method.Results Cor at T2 ,T3 was lower than that at T1 , C-P was higher than that at T1 (P <0.05)in group O,respectively;Cor at T2 ,T3 was higher than that at T1 , respectively,C-P was lower than that at T1 (P <0.05);Cor in group F was higher than that in group O,C-P in group F was lower than that in group O(P <0.05).Ins at T2 ,T3 was lower than that at T1 and was lower than that in group O(P <0.05).Conclusion Oxycodone 0.07 mg/kg early analgesia for UPPP significantly inhibits the occurrence of stress response.
