Laparoscopic living donor hepatectomy in living donor liver transplantation:a Meta-analysis
10.3760/cma.j.issn.1007-8118.2016.05.004
- VernacularTitle:腹腔镜技术在活体肝移植供肝获取中应用价值的评价
- Author:
Ning LI
;
Fan LIN
;
Minjie WEN
;
Guanghui ZHU
;
Weili GU
;
Jie CAO
- Publication Type:Journal Article
- Keywords:
Living donor liver transplantation;
Laparoscopy;
Safety;
Complication;
Meta-analysis
- From:
Chinese Journal of Hepatobiliary Surgery
2016;22(5):299-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the role of laparoscopic living donor hepatectomy in living donor liver transplantation (LDLT).Methods A systematic literature search was conducted on Medline-Pubmed,Embase,Cochrane Library to find studies on laparoscopic living donor hepatectomy for LDLT.All extracted data were analyzed using the RevMan 5 software.Results Ten studies with a total of 1 059 participants were included in this analysis.Laparoscopic donor hepatecomy (LDH) was associated with significantly less intraoperative blood loss [SMD =-0.39,95％ CI (-0.73,-0.05),P ＜ 0.05],lower peak level of postoperative total bilirubin [SMD =-0.24,95％ CI (-0.47,-0.01),P ＜ 0.05]and longer operative time [SMD =0.50,95％ CI (0.04,0.96),P ＜0.05] when compared with those operated with open surgery.On subgroup analyses,hospitalization stay decreased in patients who underwent LDLT with grafts obtained by complete living donor hepatectomy (LDH) and left lateral sectionectomy (both P ＜ 0.05).LDH was comparable to open surgery in donor complication rates and in-hospital cost (P ＞ 0.05).There were no differences on the harvested liver graft size,ischemic time,recipient postoperative liver function and complications between the two groups (P ＞ 0.05).Conclusions Laparoscopic hepatectomy in living donor is a safe procedure for graft-harvesting,which improved the clinical outcomes of the donor,liver graft and recipient in LDLT.It has also the advantages of reduced blood loss,low peak levels of postoperative total bilirubin and short hospitalization stay.
