The correlation of PIK3CA gene mutation and the efficacy of anti-HER2 targeted therapy for breast cancer
- VernacularTitle:乳腺癌 PIK3CA 基因突变与抗 HER2靶向治疗疗效的相关性
- Author:
Xiying SHAO
;
Yabing ZHENG
;
Xiaojia WANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Receptor,epidermal growth factor;
PIK3CA gene mutation
- From:
Journal of International Oncology
2016;43(9):699-702
- CountryChina
- Language:Chinese
-
Abstract:
It has been shown that the PIK3CA mutation in HER2 positive breast cancer is up to 25%, and thus activates PI3K-Akt signaling pathway,promotes HER2 mediated tumor cell epithelial transformation, alters the intrinsic phenotype of HER2 overexpression breast cancer,and finally leads to resistance to anti HER2 targeted therapy.Some studies have shown that the PIK3CA gene mutation is associated with the efficacy of anti-HER2 targeted therapy.Therefore,real-time monitoring of PIK3CA gene mutation will promote indivi-dualized anti-HER2 targeted therapy.
