Correlation between coagulation indicators and trastuzumab treatment response in breast cancer patients
10.3969/j.issn.1673-4130.2016.17.010
- VernacularTitle:乳腺癌患者凝血指标与赫赛汀治疗效应的相关性分析
- Author:
Yu XIA
;
Jing LIU
;
Lei XIN
;
Bing LIANG
- Publication Type:Journal Article
- Keywords:
breast neoplasm;
coagulation function;
fibrinogen
- From:
International Journal of Laboratory Medicine
2016;37(17):2384-2386
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the routine coagulation indicators in breast cancer patients receiving the trastuzumab treatment and to analyze the influence of the coagulation indicators on clinical treatment response .Methods Totally 67 hospitalized breast cancer patients receiving the trastuzumab treatment in 401 Hospital of PLA from Jan .2006 to Dec .2012 were collected and divided into the effective group(47 cases) and ineffective group(20 cases) according to the curative effect .The levels of PT ,APTT ,TT ,Fib and D‐D were statistically analyzed .The differences of coagulation indicators were compared between the two groups .The correla‐tion between the coagulation indicators with the curative effect was analyzed .Results Compared with the effective group ,PT , APTT and TT in the ineffective group were slightly extended ,while the D‐D level was slightly increased ,the differences were not statistically significant(P> 0 .05);but the Fib level was significantly increased with statistical difference(P< 0 .05) .Conclusion The breast cancer patients with ineffectiveness in the trastuzumab treatment are easily appear the high Fib status .Determining its plas‐ma concentration is conducive to judge the prognosis of the trastuzumab treatment in breast cancer patients .
