Expression and role of SPARCL1 gene in tumor
- VernacularTitle:SPARCL1基因在肿瘤中的表达及作用
- Author:
Shujie ZHAO
;
Dong ZHOU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Neoplasm metastasis;
Secreted protein acidic and rich in cysteine like 1 gene
- From:
Journal of International Oncology
2016;43(9):673-675
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal expression of secreted protein acidic and rich in cysteine like 1 (SPARCL1 )gene is closely related to the development,metastasis and prognosis of a variety of tumors.Recent studies show that SPARCL1 gene is high expressed in glioma.The protein product of SPARCL1 gene encoded can interact with collagen,thus affecting the metastasis ability of tumor,which is positively correlated with tumor malignant de-gree.SPARCL1 gene is low expressed in gastric cancer,colorectal cancer,prostate cancer and breast cancer, which is negatively correlated with the invasion and metastasis abilities of tumors.At present,the role of speci-fic molecular mechanisms of SPARCL1 gene remains controversial. The expressions and functions of SPARCL1 gene in tumor tissues seem to depend on the tumor microenvironment.
