Roles of microRNAs in the anti-tumor effects of metformin
- VernacularTitle:微小 RNA 在二甲双胍抗肿瘤机制中的作用
- Author:
Libo YANG
;
Xiaohong LYU
;
Shun WU
;
Feng YUE
;
Tie ZHANG
- Publication Type:Journal Article
- Keywords:
Metformin;
MicroRNAs;
Neoplasms
- From:
Journal of International Oncology
2016;43(9):681-683
- CountryChina
- Language:Chinese
-
Abstract:
Recent epidemiologic data indicate that metfomin has an anti-tumor effect.However,the underlying anti-tumor mechanisms remain unclear.MicroRNAs (miRNAs)can exhibit pro-oncogenic or anti-oncogenic effects by regulating the differentiation and proliferation of cells.In vitro studies show that metformin can regulate the expressions of multiple miRNAs which are closely associated with tumor development,a process possibly relating to the anti-cancer roles of metformin.
