Distribution and antimicrobial resistance of coagulase-negative staphylococci isolated from cerebrospinal fluids in neurosurgical patients
10.3760/cma.j.issn.1674-2397.2016.04.013
- VernacularTitle:神经外科术后患者脑脊液中凝固酶阴性葡萄球菌的菌群分布与耐药性
- Author:
Guanghui ZHENG
;
Chu ZHENG
;
Yan ZHANG
;
Mingzhong TANG
;
Fangqiang LI
;
Xiaozheng DING
;
Yanxia LIANG
;
Xixiong KANG
;
Guojun ZHANG
- Publication Type:Journal Article
- Keywords:
Staphylococcus epidermidis;
Coagulase-negative staphylococci;
Cerebrospinal fluid;
Central nervous system bacterial infections
- From:Chinese Journal of Clinical Infectious Diseases
2016;9(4):355-358
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution and antimicrobial resistance of Coagulase-negative staphylococci ( CoNS) isolated from cerebrospinal fluids in neurosurgical patients.Methods CoNS strains isolated from cerebrospinal fluids of neurosurgical patients were collected from Beijing Tiantan Hospital of Capital Medical University during January 2013 and December 2015.CoNS infection was diagnosed according to the standards of US Centers for Disease Control and Prevention, and the distribution and antimicrobial resistance of pathogenic CoNS strains were analyzed. Results A total of 19 756 cerebrospinal fluid specimens were collected and 1 386 bacterial strains were isolated, in which 650 (46.9%) were CoNS.Among 650 CoNS strains, 130 were diagnosed as the pathogen, and the top 4 CoNS species were Staphylococcus epidermidis (77/130, 59.2%), Staphylococcus hominis (18/130, 13.8%), Staphylococcus haemolyticus (11/130, 8.5%) and Staphylococcus capitis (9/130, 6.9%).The rest 520 CoNS strains were contaminating strains.According to antimicrobial susceptibility test, there were 103 strains of methicillin-resistant CoNS (MR-CoNS) accounting for 79.1% (103/130).And among 77 Staphylococcus epidermidis isolates, 67 were MR-CoNS strains (87.0%) .More than 90.0%Staphylococcus epidermidis isolates were sensitive to vancomycin and linezolid, and the rest CoNS strains were also highly sensitive to these two antibacterial agents.Conclusions CoNS plays an important role in post-surgery infection in neurosurgical patients, and Staphylococcus epidermidis is the dominant CoNS species.Most CoNS strains are methicillin-resistant, but are highly sensitive to vancomycin and linezolid.
