Research progress of thalidomide in usual non-hematologic malignancies
- VernacularTitle:沙利度胺治疗常见非血液系统肿瘤的研究进展
- Author:
Lei LEI
;
Xian WANG
;
Xiaojia WANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Therapeutic uses;
Thalidomide
- From:
Journal of International Oncology
2016;43(9):711-714
- CountryChina
- Language:Chinese
-
Abstract:
Thalidomide has anti-tumor effects such as anti-tumor angiogenesis,improvement of immune function and cachexia of patients with advanced tumors,which has been effectively used in elderly patients with castration-resistant prostate cancer,chemotherapy resistant advanced colorectal cancer,advanced hepatocellular carcinoma and metastatic breast cancer.As the in-depth study of the anti-tumor mechanism of thalidomide, more and more clinical researches have focused on the function of thalidomide on non-hematological malignan-cies,especially it has obtained some achivements in the postoperative adjuvant therapy for high-risk colorectal cancer and primary hepatocellular carcinoma and the salvage therapy for metastatic triple-negative breast cancer and refractory gynecological tumor.
