NRP1 expression is associated with chemosensitivity and poor prognosis in advanced non-small cell lung cancer patients treated with ifrst-line platinum-based chemotherapy
10.19401/j.cnki.1007-3639.2016.06.006
- VernacularTitle:NRP1表达与晚期非小细胞肺癌一线含铂方案化疗敏感性及预后的相关性分析
- Author:
Weineng FENG
;
Liangyun ZHANG
;
Haiyan SHI
;
Zecheng CHEN
;
Yicong TANG
;
Yanming DENG
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer;
Neuropilin-1;
Chemosensitivity;
Prognosis
- From:
China Oncology
2016;26(6):514-520
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Neuropilin-1 (NRP1), a vascular endothelial growth factor (VEGF) receptor, plays an important role in tumor angiogenesis and tumor cell migration. The purpose of this study was to de-termine the correlation between NRP1 expression and sensitivity to ifrst-line platinum-based chemotherapy in patients with advanced non-small cell lung cancer (NSCLC), and between NRP1 expression and survival.Methods:NRP1 ex-pression in tumor tissues of 104 advanced NSCLC patients treated with ifrst-line platinum-based regimen was detected by immunohistochemisty.A chi-square test and logistic regression model were used to analyze the relationship between NRP1 expression and the chemotherapy response rate. Kaplan-Meier and Cox proportional hazard regression models were used to analyze the effect of NRP1 expression on patient survival.Results:Among the 104 patients, 56 (53.8%) had high expression of NRP1. High expression of NRP1 was not related to age, gender, histological type, degree of differentiation, performance status, and chemotherapy regimen. The chemotherapy response rate was significantly higher in patients with low NRP1 expression than in patients with high expression (43.8% vs23.2%,P=0.026). The low NRP1 expression was signiifcantly associated with longer progression-free survival (4.6 monthsvs3.0 months, P=0.001 for log-rank test,χ2=11.273) and overall survival (11.5 monthsvs9.2 months,P=0.000 for log-rank test,χ2=14.392) as compared with high NRP1 expression. Multivariate analysis showed that high expression of NRP1 was an independent predictor for the chemotherapy response rate and overall survival in patients with advanced NSCLC.Conclusion:NRP1 expression is associated with response rate and survival in advanced NSCLC patients treated with ifrst-line plati-num-based chemotherapy. NRP1 expression may be a potential biomarker for predicting chemosensitivity and prognosis in patients with advanced NSCLC.
