Gadomer-17 in Contrast Enhanced MR Imaging of Reperfused Myocardial Infarction in a Cat Model.
10.3348/jkrs.2000.43.5.539
- Author:
Han Na NOH
1
;
Sang Il CHOI
;
Seong Hoon CHOI
;
Sang Tae KIM
;
Keun Ho LIM
;
Chung Hwan LIM
;
Tae Hwan LIM
Author Information
1. Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Soeul, Korea. thlim@www.amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Myocardium, infarction;
Magnetic resonance (MR), contrast agent
- MeSH:
Animals;
Cats*;
Magnetic Resonance Imaging*;
Myocardial Infarction*;
Myocardium;
Reperfusion
- From:Journal of the Korean Radiological Society
2000;43(5):539-544
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate in reperfused myocardial infarction in a cat model, the time-course of signal enhancement as seen on Gadomer-17 enhanced MRI, and to correlate the size of the enhanced area with that of the infarct area as revealed by on histochemical examination. MATERIALS AND METHODS: Five cats which had undergone occlusion of the LAD followed by reperfusion underwent MR imaging. After T2-weighted imaging, Gadomer-17 enhanced T1-weighted images were obtained in four cats during a six-hour period, and in one during a three-hour period. Signal intensities were measured in the enhanced and non-enhanced areas of enhanced T1-weighted images. and using 2,3,5-triphenyl tetrazolium chloride (TTC) histochemical staining, the size of the abnormal signal area on each image was compared with that of the infarct area. RESULT: The enhanced area seen on enhanced T1-weighted images showed rapidly increased signal intensity following the administration of Gadomer-17. Maximum enhancement was detected during a 40 -60 minutes period, with an average enhancement of 168 +/-9.9% of normal myocardium. TTC staining revealed that the size of the high signal area on T2-weighted images and of the enhanced area on enhanced T1-weighted images was greater than that of the infarct area (p<0.05). CONCLUSION: In reperfused myocardial infarction in a cat model, Gadomer-17 enhanced MR imaging delineates both reversibly and irreversibly damaged myocardium, with strong enhancement and a broad temporal window. We may therefore expect that Gadomer-17 is useful for demonstrating myocardial injury.
