The role of mitochondrial permeability transition pore in the occurrence of septic myocardial depression

VernacularTitle:线粒体通透性转换孔在脓毒症心肌抑制发生过程中的作用
Author: Shanzi JIN ; Sheng WANG
Publication Type:Journal Article
Keywords: Sepsis; Septic myocardial depression; Mitochondrial injury; Mitochondrial permeability transition pore
From: Chinese Critical Care Medicine 2016;28(8):747-751
CountryChina
Language:Chinese
Abstract: Sepsis is defined as life-threatening organ dysfunction caused by a dys-regulated host response to infection and septic myocardial depression (SMD) is a common complication. Pathogenesis of SMD is complicated and there is lack of specific treatment. Mitochondrial damage is an important pathological basis of SMD, and mitochondrial permeability transition pore (MPTP) plays an important role in maintaining the normal structure and function of the mitochondria. The change of MPTP during sepsis is summarized in this review so as to reveal the significant mechanism of MPTP in the occurrence of SMD.