Meta Analysis for the Relationship Between the Levels of Serum Uric Acid and Prevalence of Coronary Artery Disease

VernacularTitle:血尿酸水平与冠心病发病关系的剂量-反应 Meta 分析
Author: Yongbin LU ; Zhiyuan CHENG ; Yaxue ZHAO ; Xiaoyu CHANG ; Ning CHENG
Publication Type:Journal Article
Keywords: Uric acid; Coronary artery disease
From: Chinese Circulation Journal 2016;31(7):640-643
CountryChina
Language:Chinese
Abstract: Objective: To evaluate the relationship between the levels of serum uric acid (SUA) and prevalence of coronary artery disease (CAD) by Meta analysis. Methods: We searched the databases of Pub Med, Elsevier and Web of Science for internationally published cohort study for the relationship between SUA levels and CAD prevalence and conducted a general analysisby using Stata software. Results: A total of 11 cohort study including 463,918 subjects were enrolled in this study. For both male and female genders, increase SUA level was the risk factor for CAD occurrence (RR=1.11, 95% CI 1.00-1.24) and (RR=1.24, 95% CI 1.15-1.34). Dose-response Meta-analysis indicated that by 1 mg/dl SUA elevation, the risk of CAD occurrence would increase 4.8% in male and 12.4% in female, the risk in female gender was higher than male. Conclusion: SUA level has been closely related to CAD prevalence.