Role of nuclear factor-κB signaling pathway in inflammatory lung diseases
10.3867/j.issn.1000-3002.2016.07.009
- VernacularTitle:核因子κB信号通路在炎症性肺部疾病中的作用
- Author:
Xiuhe PAN
;
Chaobo LIU
;
Jun SUN
;
Yan LI
;
Mingcai LI
- Publication Type:Journal Article
- Keywords:
NF-κB;
asthma;
chronic obstructive pulmonary disease;
inhibitors
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(7):762-769
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor(NF)-κB is widely expressed in various types of tissue cells. Abnormal activation of NF-κB signaling pathway can lead to the initiation and progression of asthma,chronic ob?structive pulmonary disease(COPD)and other lung inflammatory diseases,but inhibition of its activity can effectively alleviate the occurrence and development of these diseases. In this paper ,we review biological characteristics of NF-κB,role of NF-κB signaling in asthma,COPD and other inflammatory lung diseases,and potential application of NF-κB inhibitors in clinical treatment of these inflammatory lung diseases. It will provide a valuable reference for further study on pathogenesis,prevention,and control of lung inflammatory diseases.
