Role of tyrosine kinase receptor RON in tumor growth and metastasis:research progress

VernacularTitle:受体型酪氨酸激酶RON及其在恶性肿瘤发生发展中的作用研究进展
Author: Qi MA ; Bixia YU ; Junfeng CHEN ; Yue CHENG
Publication Type:Journal Article
Keywords: tyrosine kinase receptor; RON; cancer; target therapy
From: Chinese Journal of Pharmacology and Toxicology 2016;30(7):784-789
CountryChina
Language:Chinese
Abstract: Recepteur d′origine Nantais(RON),a tyrosine kinase receptor ,is a growth factor receptor belonging to the proto-oncogene met family and has been proved to display abnormal expres?sion in many types of tumors. The RON receptor is activated by binding to the ligand macrophage stim?ulating protein,overexpression of the receptor,variants of the proto-oncogene and by point mutations of the kinase region. The downstream transduction of RON by mitogen-activated protein kinases and phosphoinositide3-kinase signaling pathways can help regulate the proliferation,apoptosis,migration and invasion of tumor cells. A better understanding of the mechanisms and related signaling pathways of RON activation in tumor progress and development will provide more information for the RON-based target therapy.