Correlation Study Between Aspirin Resistance and COX1, COX2, TBXA2R Gene Polymorphisms in Patients With Coronary Artery Disease
10.3969/j.issn.1000-3614.2016.07.006
- VernacularTitle:阿司匹林抵抗与环氧化酶-1、环氧化酶-2及血栓烷A2受体基因多态性相关性研究
- Author:
Jingjing XU
;
Xiaofang TANG
;
Yi YAO
;
Na XU
;
Jiahui ZHANG
;
Yuanliang MA
;
Ying SONG
;
Jinqing YUAN
- Publication Type:Journal Article
- Keywords:
Aspirin resistance;
Polymorphism,single nucleotide;
Gene
- From:
Chinese Circulation Journal
2016;31(7):644-648
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore aspirin resistance (AR) phenomenon in patients with coronary artery disease (CAD) for secondary prevention and to study the relationships between AR and COX1, COX2, TBXA2R gene polymorphisms. Methods: A total of 2881 CAD patients taken aspirin (100 mg/day) in 7 consecutive days were enrolled. Among them, 2 groups were established as AR group, n=166 and Control group, n=200 aspirin sensitive patients. Platelet aggregation function was induced by arachidonic acid (AA), COX1, COX2 and TBXA2R gene polymorphisms were examined by polymerase chain reaction-restricted fragment length polymorphisms (PCR-RFLP) method. Results: The occurrence rate of AR was 5.76% (166/2881). There were 8 tagSNPs locus in 3 genes as in COX1:(rs3842788), (rs4273915), (rs7866582); in: COX2 (rs3218625); in TBXA2R: (rs2238630), (rs2238631), (rs2238633), (rs3786989). The frequencies of wild type, heterozygous genotype and homozygous genotype were similar between 2 groups. Conclusion: The incidence rate of AR is not high in CHD patients with regular aspirin medication; single nucleotide gene polymorphisms of COX1, COX2 and TBXA2R have no obvious correlation to AR.
