Application of Child-Turcotte-Pugh Scores in Predicting the Risk of Death for In-hospital Heart Failure Patients
10.3969/j.issn.1000-3614.2016.07.011
- VernacularTitle:肝功能 Child-Turcotte-Pugh 评分在住院心力衰竭患者风险评估中的应用
- Author:
Xuemei ZHAO
;
Yuhui ZHANG
;
Rongcheng ZHANG
;
Yan HUANG
;
Yiran HU
;
Xiaoning LIU
;
Mei ZHAI
;
Yunhong WANG
;
Tao AN
;
Tianyi GAN
;
Jian ZHANG
- Publication Type:Journal Article
- Keywords:
Heart failure;
Death;
Child-Turcotte-Pugh scores
- From:
Chinese Circulation Journal
2016;31(7):668-672
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Heart failure (HF) patients are usually associated with liver function impairment, Child-Turcotte-Pugh (CTP) scores can evaluate liver function, but its effect in HF patients has been unclear. We want to study the application of CTP scores in predicting the risk of death for in-hospital HF patients. Methods: A total of 1180 consecutive in-hospital HF patients were enrolled. According to CTP scores evaluated liver function at admission, the patients were divided into 3 groups: CTP grade A group, n=951, CTP grade B group, n=206 and CTP grade C group, n=23. The endpoint of this study was all-cause death. Results: There were 180 patients died at 1 year follow-up period, the in-hospital and 1 year mortalities were increased with the elevated CTP grades accordingly: for in-hospital mortalities in CTP grade A, B and C groups were (0.8%, 11.7% and 56.5%) respectively, P< 0.001; for 1 year mortalities were (9.6%, 34.5% and 78.3%) respectively, P< 0.001. Multivariable Cox regression analyses indicated that the higher CTP grades, the higher risk of in-hospital and 1 year mortalities in HF patients. The area under curve for CTP scores in predicting the in-hospital and 1 year mortalities were 0.88 and 0.74 respectively. Kaplan-Meier survival analysis presented that the patients with improved CTP scores from grade B or C to grade A at discharge had the higher 1 year survival rate than those without improvement, P=0.028.
Conclusion: CTP scores may independently predict the risk of death for in-hospital HF patients, the levels of CTP scores might be used for evaluating the efficacy of in-hospital treatment.
