Regulation of exosomes in tumor:research progress
10.3867/j.issn.1000-3002.2016.07.011
- VernacularTitle:外泌体在肿瘤发生中的调节作用研究进展
- Author:
Chengcheng LYU
;
Yunfeng ZHU
- Publication Type:Journal Article
- Keywords:
exosome;
tumor;
tumor diagnosis;
biomarkers
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(7):777-783
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are extracellular nanoparticles secreted by multiple types of cells,which are enriched for some bioactive molecules,such as proteins,messcge RNA(mRNA),micro RNA(miRNA), DNA and lipid. These molecules are documented to be involved in the process of intercellular material exchange and signal communication,thus affecting the function of cells. Also,exosomes are considered to participate in tumor angiogenesis,cancer progression and metastasis,but the mechanism remains obscure. Exosomes are of great value for the diagnosis and treatment of tumor. The correlations between exosomes and tumorigenesis and tumor metastasis as well as their clinical applications are summarized in this review.
