Relationship Between Slow Coronary Flow and Coronary Microcirculatory Dysfunction in Relevant Patients
10.3969/j.issn.1000-3614.2016.06.008
- VernacularTitle:冠状动脉慢血流与冠状动脉微循环障碍的相关性研究
- Author:
Peiming YIN
;
Shuguang WANG
;
Aiyuan ZHANG
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Coronary circulation;
Blood feow velocity;
Inlfammation
- From:
Chinese Circulation Journal
2016;31(6):555-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the relationship between slow coronary lfow (SCF) and coronary microcirculatory dysfunction in relevant patients and to explore the risk factors for SCF development. Methods: Our research was conducted in 2 groups: SCF group, the patients with coronary angiography conifrmed diagnosis and Control group, the subjects with normal coronary lfow.n=32 in each group. The general information, blood levels of biochemical indicators, hs-CRP levels, TIMI lfow frame and the index of microcirculatory resistance (IMR) were examined, their relationships to SCF were analyzed. Results: Compared with Control group, the patients in SCF group showed the lower levels of HLL-C (1.57 ± 0.38) mmol/L vs (1.62 ± 0.43) mmol/L and Apo-A1 (1.41 ± 0.31) mmol/L vs (1.57 ± 0.38) mmol/L, while higher level of hs-CRP (3.63 ± 1.67) μg/mL vs (1.74 ± 0.75) μg/mL; SCF groups had increased IMR (29.28 ± 7.68) vs (24.94 ± 6.67), all P<0.05. IMR was positively related to TIMI lfow frame (r=0.766, P=0.019) and hs-CRP (r=0.565, P=0.000). Conclusion:①Microcirculatory dysfunction was related to SCF.②Inlfammatory reaction, decreased blood levels of HDL-C and Apo-A1 might be involved in pathological process of SCF.
