Relationship Between Thyroid Hormone Levels and Prolonged Recovery After Cardiac Surgery With Cardiopulmonary Bypass in Congenital Heart Disease Children Younger Than 1 Year of Age
10.3969/j.issn.1000-3614.2016.06.015
- VernacularTitle:1岁以下先天性心脏病患儿体外循环下心脏术后甲状腺激素水平与延迟恢复的关系
- Author:
Sixing CHEN
;
Xia LI
;
Zhongyuan LU
;
Xu WANG
- Publication Type:Journal Article
- Keywords:
Thyroid hormone;
Heart defects,congenital;
Prolonged recovery
- From:
Chinese Circulation Journal
2016;31(6):588-592
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship between thyroid hormone levels and prolonged recovery after cardiac surgery with cardiopulmonary bypass (CPB) in congenital heart disease (CHD) children younger than 1 year of age. Methods: A total of 186 CHD children younger than 1 year treated in our hospital from 2014-01 to 2015-01 were retrospectively summarized. According to the pediatric intensive care unit (PICU) stay time, the patients were divided into 2 groups: Prolonged recovery group, the patients stated in PICU≥5 days,n=39 and Non-prolonged recovery group, the patients stayed in PICU<5 days,n=147. Thyroid hormone levels within 24 hours of operation with prolonged recovery conditions were studied. Results: Compared with Non-prolonged recovery group, the patients in Prolonged recovery group showed decreased levels of FT3 (2.02 ± 0.48) pg/ml vs (2.27 ± 0.46) pg/ml, TT3 (0.59 ± 0.30) ng/dl vs (0.71 ± 0.24) ng/dl and TT4 (5.39 ± 2.58)μg/ml vs (6.49 ± 2.20) μg/ml, allP<0.05; while the levels of free thyroid hormone and thyrotropin were similar between 2 groups,P>0.05. Multivariable logistical regression analysis presented that low level of FT3 within 24 hours of operation was the independent risk factor for prolonged recovery (OR= 0.32, 95% CI 0.12-0.84,P=0.02); linear regression analysis indicated that post-operative reduction of thyroid hormone was related to low body weight of the patients (r=0.11,P<0.001). Conclusion: Lower body weight was usually having lower level of FT3 within 24 hours of operation, which was the independent predictor for prolonged recovery in CHD children younger than 1 year after cardiac surgery.
