Assessment of effect of laboratory external quality assessment program on cytogenetic testing
10.3969/j.issn.1671-8348.2016.21.011
- VernacularTitle:实验室室间质评染色体检测水平效果分析
- Author:
Xi CHEN
;
Yuanyuan CHEN
;
Qin MU
;
Jing YANG
;
Ling FAN
;
Dayong ZHANG
;
Zhiguo WANG
;
Hu DOU
;
Lin ZOU
;
Liming BAO
- Publication Type:Journal Article
- Keywords:
cytogenetics;
external quality assessment;
proficiency test
- From:
Chongqing Medicine
2016;45(21):2917-2919
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the change of chromosome test level after participating in the inter‐laboratory proficiency test(PT) program of the College of American Pathologists (CAP) .Methods The results for participating in CAP PT during 2011-2014 were analyzed ,the accuracy of the cytogenetic chromosome quality control test in this laboratory was obtained accord‐ing to the CAP evaluation results ,and the effect of CAP external quality assessment item on increasing the chromosome detection level in this laboratory was evaluated by analyzing the chromosome band levels before and after participating in CAP .Results This laboratory participated in CAP PT test for 10 times during 2011-2014 ,a total of 59 cases were analyzed ,the accuracy rate for jud‐ging chromosome karyotype was 100% ,the karyotype description accuracy rate was 95 .1% .The chromosome test results of clinical cases in this laboratory displayed that peripheral blood chromosome abnormal detection rate was 18 .9% and bone marrow chromo‐some abnormal detection rate was 25 .9% ,the abnormal rate of newly diagnosed leukemia was 66 .8% ;the detection failure rates of peripheral blood chromosome and bone marrow chromosome were 0 .5% and 5 .0% respectively ;the detection failure rates of pe‐ripheral blood chromosome and bone marrow chromosome after participating in CAP were decreased ,the chromosome band average level was improved ,showing statistical difference compared with those before participating in CAP (P<0 .01) .Conclusion Partici‐pating in high quality external laboratory assessment item can increase the clinical analytic level of cytogenetic chromosome test .
