The effect of botulinum toxin injection to the external urethral sphincter on detrusor wall thickness in patients with detrusor-sphincter dyssynergia
10.3760/cma.j.issn.0254-1424.2016.06.006
- VernacularTitle:肉毒毒素注射尿道外括约肌对逼尿肌-尿道外括约肌失协调患者逼尿肌厚度的影响
- Author:
Hongjun ZHU
;
Weixin YANG
;
Nan SU
;
Chuandao LIU
;
Yunqiang ZAN
- Publication Type:Journal Article
- Keywords:
Botulinum toxin A;
Detrusor wall thickness;
Spinal cord injury;
Detrusor-sphincter dyssynergia
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2016;38(6):421-424
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of injecting botulinum toxin A (BTX-A) to the external urethral sphincter on detrusor wall thickness (DWT) and the bladder function of spinal cord injury patients with detrusor-sphincter dyssynergia (DSD).Methods Twenty-one adult patients with DSD due to spinal cord injury were recruited.A single 100 IU dose of botulinum toxin A was injected into their external urethral sphincters via an uhrasound-guided transperineal route.DWT,detrusor leak-point pressure (DLPP),post-void residual volume (PRV) and maximum bladder capacity(MBC) were assessed by urodynamic examination and ultrasound evaluation before and 4 and 8 weeks after the injection.Results Four weeks later a significant decrease in PRV was observed,but no significant difference in DWT,DLPP or MBC.After eight weeks the mean DWT value had decreased by 17％,a significant reduction.There were also significant improvements in DLPP,PRV and MBC at eight weeks compared with the of baseline values.Conclusions BTX-A injection to the external urethral sphincter can reduce DWT and improve bladder function in spinal cord injury patients with DSD.
