Mechanisms of transcutaneous immunization and its application in allergic diseases

VernacularTitle:经皮免疫机制及其在过敏性疾病的应用进展
Author: Xiaochun LIU ; Xu YAO
Publication Type:Journal Article
Keywords: Skin diseases; Anaphylaxis; Immunity; Vaccines; Therapeutic uses
From: Chinese Journal of Dermatology 2016;49(6):441-444
CountryChina
Language:Chinese
Abstract: Transcutaneous immunization (TCI) is a novel immunotherapy approach that induces systemic immune responses via topical application of antigens and adjuvants onto the skin.It is a safe and effective method,and is expected to serve as an attractive alternative to traditional vaccination.TCI induces immune responses in different directions,but the exact mechanism of skin immune tolerance is still unclear.Most studies on TCI are based on animal models.However,there are structural differences between animal skin and human skin,so more researches are needed to achieve the translation of TCI from bench to bedside.Not all vaccines are suitable for cutaneous inoculation,so vaccines for TCI should be evaluated for their safety and efficacy.Various reformed vaccine delivery systems are needed to be further explored in related diseases.