The correlation study between the changes of intestinal mucosa predominant bacteria and Toll-like receptor 2, Toll-like receptor 4 gene expressions in diarrhea-predominant irritable bowel syndrome patients
10.3760/cma.j.issn.0578-1426.2016.07.011
- VernacularTitle:腹泻型肠易激综合征患者肠黏膜优势菌的改变与Toll样受体2和4基因表达的相关性研究
- Author:
Wentao GUO
;
Ping LIU
;
Lina DONG
;
Junping WANG
- Publication Type:Journal Article
- Keywords:
Irritable bowel syndrome;
Toll-like receptor;
Intestinal flora
- From:
Chinese Journal of Internal Medicine
2016;55(7):541-543
- CountryChina
- Language:Chinese
-
Abstract:
Based on high throughput sequencing and PCR detection technology,this study has found out that intestinal microbial diversity was impaired and the quantities of two main bacteria flora (Bacteroidetes and Clostridium) were significantly reduced in patients with diarrhea-predominant irritable bowel syndrome (D-IBS).Meanwhile mucosal expression of toll-like receptor (TLR) 2 and TLR4 were significantly enhanced,which was inversely correlated with the reduction of Bacteroidetes and Clostridium.Thus,it suggests that D-IBS may be associated with TLR signal transduction triggered by the intestinal dysbacteriosis.
