Effect of ulinastatin on brain injury in pediatric patients undergoing living-related liver transplantation
10.3760/cma.j.issn.0254-1416.2016.04.002
- VernacularTitle:乌司他丁对亲体肝移植术患儿脑损伤的影响
- Author:
Hongli YU
;
Hongyin DU
;
Lili JIA
;
Wenna LIU
;
Yiqi WENG
;
Wenli YU
- Publication Type:Journal Article
- Keywords:
Trypsin inhibitors;
Liver transplantation;
Child;
Brain injuries
- From:
Chinese Journal of Anesthesiology
2016;36(4):389-391
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ulinastatin on brain injury in the pediatric patients undergoing living-related liver transplantation (LRLT).Methods Sixty pediatric patients with congenital biliary atresia,of both sexes,aged 6-10 months,weighing 6.5-9.5 kg,of American Society of Anesthesiologists physical status Ⅲ or Ⅳ,scheduled for elective LRLT,were randomly divided into either control group (group C,n =30) or ulinastatin group (group U,n =30) using a random number table.Starting from the end of anesthesia induction to the end of surgery,ulinastatin 10 000 U/kg was infused intravenously in group U,while the equal volume of normal saline was infused intravenously in group C.Before operation,at 30 min of anhepatic phase,and at 3 and 24 h of neohepatic phase,blood samples were drawn from the central vein for determination of the concentrations of S-100β protein and neuron-specific enzyme in serum (by enzyme-linked immunosorbent assay) and concentrations of interleukin-6 (IL-6),IL-10 and IL-18 in serum (by radio-immunity method).Results Compared with group C,the serum concentrations of S-100β protein,neuron-specific enzyme,IL-6 and IL-18 were significantly decreased,and the serum concentration of IL-10 was significantly increased at 30 min of anhepatic phase and 3 and 24 h of neohepatic phase in group U (P＜0.05).Conclusion Ulinastatin 10 000 U/kg infused intravenously during operation can reduce brain injury in the pediatric patients undergoing LRLT.
