Insulin Resistance During Pregnancy.
- Author:
Kyu Jeung AHN
1
Author Information
- Publication Type:Review
- Keywords: Cytokines; Insulin resistance; Placental hormones; Pregnancy
- MeSH: Chorionic Gonadotropin; Cytokines; Estrogens; Female; Growth Hormone; Humans; Hydrocortisone; Insulin; Insulin Resistance; Leptin; Lipogenesis; Lipolysis; Placental Hormones; Placental Lactogen; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Third; Progesterone; Prolactin; Resistin; Tumor Necrosis Factor-alpha
- From:Korean Diabetes Journal 2009;33(2):77-82
- CountryRepublic of Korea
- Language:Korean
- Abstract: Pregnancy is a complex metabolic state involving dramatic alterations in the hormonal or cytokine environments (increases in estrogen, progesterone, prolactin, cortisol, human chorionic gonadotropin, placental growth hormone and human placental lactogen, TNF-alpha, resistin, leptin, and a decrease in adiponectin) as well as an increasing burden of fuel utilization by the conceptus. Metabolically, the first trimester is characterized by increased insulin sensitivity and lipogenesis. The second and third trimesters, in contrast, are characterized by insulin resistance and increased lipolysis.
