Impaired Wound Healing in Diabetes Mellitus.
- Author:
Min Jeong KWON
1
;
Jeong Hyun PARK
Author Information
- Publication Type:Review
- Keywords: Diabetes mellitus; Skin ulcer; Wound healing
- MeSH: Cell Movement; Diabetes Mellitus; Extracellular Matrix; Genetic Therapy; Humans; Hyperglycemia; Inflammation; Oxygen; Skin; Skin Ulcer; Stem Cells; Wound Healing
- From:Korean Diabetes Journal 2009;33(2):83-90
- CountryRepublic of Korea
- Language:Korean
- Abstract: The normal healing of a cutaneous wound is achieved via well-orchestrated integration of complex biological and molecular events of cell migration, proliferation, extracellular matrix deposition and tissue remodeling. Chronic wounds fail to progress through the normal stages of healing, and enter a state of pathologic inflammation. Complicated diabetic patients show delayed wound healing caused by multiple factors including vascular insufficiency, abnormalities of the biochemical environment and hyperglycemia per se. Novel technologies including growth factor therapy, gene therapy, stem cell technologies, synthetic skins and hyperbaric oxygen treatment are under development. In the near future, these therapeutic strategies will be clinically available.
