Everolimus after liver transplantation: a Meta-analysis
10.3760/cma.j.issn.1007-8118.2016.07.007
- VernacularTitle:肝移植术后应用依维莫司的Meta分析
- Author:
Liang YU
;
Dong ZHANG
;
Fei PAN
;
Qiang HE
;
Ren LANG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Everolimus;
Calcineurin inhibitors;
Renal function;
Meta-analysis
- From:
Chinese Journal of Hepatobiliary Surgery
2016;22(7):454-459
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare everolimus (EVR) with calcineurin inhibitor (CNI) minimization or withdrawal on renal function of liver transplant patients with standard CNI therapy.Methods A search was conducted on databases which included the PubMed,Embase and Cochrane library for randomized controlled trials (RCTs) comparing EVR with CNI with minimization or withdrawal (the EVR group) with standard CNI therapy (the standard CNIs group) on renal function of liver transplant patients.A metaanalysis was performed using RevMan 5.3 software.Results Five RCTs which included 1 264 patients were selected into this study.There were 790 patients in the EVR group and 474 patients in the standard CNIs group.On meta-analysis,the EVR group had significantly better renal function (SMD =0.36,95％ CI 0.09 ～ 0.64,P ＜ 0.05),but higher rates of infection (RR =1.37,95％ CI 1.08 ～ 1.74,P ＜ 0.05),dyslipidemia (RR =2.46,95％ CI 1.79 ～ 3.38) and leukopenia (RR =2.37,95％ CI 1.32 ～ 4.26).No significant differences were found on the mortality and the acute rejection rates between the two groups (all P ＜ 0.05).Conclusions EVR with CNI minimization or withdrawal after liver transplantation provided effective immunosuppression and improved patients' renal function.The treatment increased the rates of infection,dyslipidemia and leukopenia.
